4/1/2024 0 Comments Ion discover dj fl![]() ![]() While this technique is sensitive to detecting ligand interactions and alterations in receptor dynamics, it also can provide important mechanistic insights into ligand regulation. Differential hydrogen/deuterium exchange (HDX) coupled with mass spectrometry has emerged as a rapid and sensitive approach for characterization of perturbations in conformational dynamics of proteins following ligand binding. Functional regulation of ligand-activated receptors is driven by alterations in the conformational dynamics of the protein upon ligand binding.
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